Comprehensive structural and functional characterization of your proteins. From biophysical analysis to post-translational modification profiling, we provide the data you need for publication, patent applications, and therapeutic development.
Comprehensive characterization establishes identity, purity, structure, and function—critical for research credibility and regulatory approval.
Confirm your protein's sequence, modifications, and mass. Critical for recombinant protein quality control and biosimilar development.
Assess secondary/tertiary structure, thermal stability, and oligomeric state. Essential for structural biology and formulation development.
Quantify enzymatic activity, binding affinity, and biological function. Required for enzyme therapeutics and biomarker validation.
Comprehensive suite of analytical methods for complete protein characterization
Comprehensive characterization of protein physical properties including structure, stability, and aggregation behavior.
High-resolution mass spectrometry for molecular weight determination, sequence verification, and modification analysis.
Quantitative assessment of protein purity and aggregation state using electrophoretic and chromatographic methods.
Comprehensive glycan characterization including glycan profiling, site occupancy, and glycan structure elucidation.
Determine melting temperatures (Tm), stability profiles, and formulation conditions using multiple thermal methods.
Surface plasmon resonance (SPR), isothermal titration calorimetry (ITC), and ELISA services for interaction analysis.
State-of-the-art instrumentation for precise, reproducible characterization
Thermo Q Exactive HF-X for intact mass, peptide mapping, and PTM analysis. Bruker ultrafleXtreme MALDI-TOF/TOF for rapid fingerprinting.
JASCO J-1500 for far-UV and near-UV CD analysis. Secondary structure quantification and thermal denaturation curves.
Malvern Panalytical VP-CAP DSC for thermal stability. Affinity Instruments ITC200 for binding thermodynamics.
Wyatt DAWN HELEOS-II for SEC-MALS. Malvern Zetasizer for DLS and zeta potential measurements.
Expertise, quality, and comprehensive reporting for your characterization needs
Our characterization reports follow ICH and FDA guidelines. Suitable for IND submissions, BLA filings, and patent applications. Full audit trail and method validation documentation available.
Combine characterization with our expression and purification services for complete protein development. Single source for expression, purity, and structural/functional data.
Our scientists provide more than raw data—they offer interpretation, troubleshooting, and recommendations. Identify issues early and optimize your protein development.
From singlemethod analysis to comprehensive characterization packages. Customized to your project needs and budget. Volume discounts for multiple samples.
We discuss your protein and application to recommend the optimal characterization strategy and methods.
Initial quality check to verify sample integrity and concentration before analytical testing begins.
Comprehensive analytical testing using orthogonal methods to ensure complete characterization.
Comprehensive report with data, interpretation, and expert recommendations for your next steps.
Recommendations depend on your protein type and application. For general recombinant proteins, we typically recommend intact mass, SDS-PAGE purity, SEC-MALS for aggregation, CD for secondary structure, and DSC for thermal stability. Contact us to discuss your specific requirements.
Requirements vary by method. Most analyses require 0.1-1 mg of purified protein. For large-scale PTM analysis or glycosylation studies, we may need 2-5 mg. We can work with lower amounts for preliminary analysis.
Standard characterization packages complete in 1-2 weeks. Rapid analysis for time-sensitive projects available. Complex PTM analysis or custom assays may require 3-4 weeks.
Yes. For challenging proteins or novel applications, we develop custom characterization methods. This includes assay optimization, specificity testing, and validation according to ICH guidelines.
Absolutely. Comparability studies are a key service for biosimilar development and process changes. We provide side-by-side analysis using orthogonal methods with statistical comparison of results.
Contact us to discuss your characterization requirements and receive a customized proposal.
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